The Detroit Lions will face off against the Arizona Cardinals at 4:25 ET on Sunday, September 22nd. This matchup is being played at State Farm Stadium in Glendale.

The over/under line is set at 52.5 points for the week three matchup between the Lions and Cardinals. The Lions are favored on the road with a money line of -149. The Lions and Cardinals will kick off at 4:25 ET on Sunday, and the game will be televised on FOX. The Cardinals’ money line odds are +125, and the Lions are -3 point favorites on the road.

• Date: Sunday, September 22nd
• Time: 4:25 ET
• Location: State Farm Stadium, Glendale
• TV: FOX

Lions vs Cardinals

The Lions are now 1-1 after falling to the Buccaneers 20-16 in their most recent game. Detroit was favored by -7.5, and with the 4-point loss, they did not cover the spread. The combined 36 points was well short of the over/under line of 52 points. The Lions got off to a slow start, with the Buccaneers leading 6-3 after the 1st quarter.

Detroit added a field goal in the 2nd to tie the game at 6, but Tampa Bay scored a touchdown to end the half. In the 3rd quarter, the Lions took the lead with a 1-yard touchdown run from David Montgomery. However, Baker Mayfield’s 11-yard touchdown run for the Buccaneers with 42 seconds left in the 3rd put them ahead for good. Detroit couldn’t score in the 4th to pull off the comeback.

Arizona’s 41-10 win over the Rams evened their record at 1-1. The Cardinals jumped out to a 14-0 lead after the 1st quarter and never looked back, leading 24-3 at halftime. They added a touchdown in each of the final two quarters to secure the 31-point victory. Arizona also got a big game from James Conner, who rushed for two touchdowns.

Kyler Murray threw two first-quarter touchdowns to Marvin Harrison Jr., and Elijah Higgins added another touchdown reception in the 2nd quarter. The over/under line for the game was 47.5 points, and the Cardinals and Rams combined for 51 points.

Lions Injury Report

• Tre’Quan Smith – Undisclosed (Out)
• Marcus Davenport – Groin (Questionable)
• Alex Anzalone – Concussion (Questionable)
• Netane Muti – Shoulder (Out)
• Emmanuel Moseley – Pectoral (Out)
• Michael Badgley – Hamstring (Out)
• John Cominsky – Knee (Out)
• Amon-Ra St. Brown – Lower Body (Questionable)
• Ifeatu Melifonwu – Ankle (Questionable)
• Connor Galvin – Knee (Out)
• Antoine Green – Concussion (Out)
• Brodric Martin – Knee (Out)
• Terrion Arnold – Finger (Questionable)
• Isaiah Williams – Abdomen (Questionable)
• Christian Mahogany – Illness (Out)
• Nate Lynn – Shoulder (Out)

Cardinals Injury Report

• Zay Jones – Suspension (Out)
• Jonah Williams – Knee (Out)
• Carter O’Donnell – Undisclosed (Out)
• BJ Ojulari – Knee (Out)
• Xavier Weaver – Oblique (Questionable)
• Elijah Jones – Heel (Out)
• Christian Jones – Ankle (Out)
• Darius Robinson – Calf (Out)

Lions Offense Breakdown

In their 20-16 loss to the Buccaneers, the Lions’ offense recorded 26 first downs and 324 yards passing. However, they were unable to find the endzone through the air, with Jared Goff throwing for 307 yards on 34 completions. Goff also threw two interceptions and was not helped by a running game that managed just 139 yards on 27 attempts.

Jahmyr Gibbs led the team with 84 yards on 13 carries, while Amon-Ra St. Brown had a big game receiving, catching 11 passes for 119 yards. The Lions’ offense struggled on third down, converting just 41.2% of their attempts, and Goff was not sacked in the game.

Cardinals Offense Breakdown

Arizona’s offense was firing on all cylinders in their 41-10 win over the Rams, piling up 24 first downs and 231 yards on the ground. Kyler Murray completed 17 of 21 passes for 266 yards and three touchdowns, finishing with a passer rating of 158 and adding 59 rushing yards. The Cardinals’ ground game was led by James Conner, who ran for 122 yards, averaging 5.8 yards per attempt, and found the end zone once.

Marvin Harrison Jr. was the top receiver for Arizona, with 130 yards and two touchdowns. The Cardinals’ offense was efficient, converting 63.6% of their third down attempts and allowing just one sack in the game.

Lions Team Defense

In their 20-16 loss to the Buccaneers, the Lions’ defense held Tampa Bay to just 70 yards on 23 rushing attempts, averaging 3.0 yards per attempt. Despite this, Detroit’s offense fell short in the end. The Lions’ defense limited the Buccaneers to 146 passing yards on 12 completions, with one touchdown. They also picked off one pass and allowed a 63.2% completion rate. Additionally, Detroit’s defense recorded five sacks and held Tampa Bay to a 20% third-down conversion rate.

Cardinals Team Defense

Arizona’s defense was dominant in their 41-10 win over the Rams, allowing just 53 rushing yards on 20 attempts and holding the Rams to 2.6 yards per attempt on the ground. The Cardinals’ defense also recorded five sacks and limited the Rams to an 18.2% conversion rate on third down.

Against the pass, the Cardinals gave up 192 yards through the air, with the Rams completing 70.4% of their passes. Arizona didn’t allow any passing touchdowns and won the QB hit differential by eight and the tackles for loss differential by six.

Lions vs Cardinals Trends

• In their last five road games, Detroit has averaged 25 points per game while allowing 26. The team’s record in this stretch was 2-3 while going 4-1.
• In their last ten games at home, the Cardinals have a straight up record of 2-8 while going 5-5 vs. the spread. The team averaged 17 points per game in this stretch.
• Spanning across their last ten games as the betting underdog, the Cardinals have gone 6-4 vs the spread. Their overall record in these games was 3-7.
• Detroit has done well both straight up and vs the spread when favored to win the game, going 2-1 SU and 2-1 ATS in their last three games.

Lions vs Cardinals Prediction

With the point spread sitting at 52.5, our pick is to take the under, as we have this one finishing with 47 combined points. As for the point spread, we like the Cardinals to not only win but cover as home underdogs.

Our projected final score is 25-22 in favor of Arizona, making them our best bet to cover at +3. If you are looking to make a play on the moneyline, we have the Cardinals winning this one outright.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.