The San Francisco 49ers will face off against the Los Angeles Rams at 4:25 ET on Sunday, September 22nd. This matchup is being played at SoFi Stadium in Inglewood.

The 49ers are favored on the road with a money line of -349, and the Rams are +276 on the money line. The point spread has the 49ers -7, and this week three NFC West matchup is being played at SoFi Stadium in Inglewood, CA. The over/under line is set at 43.5 points, and this one is on FOX at 4:25 ET. The Rams and 49ers need to add their current records.

• Date: Sunday, September 22nd
• Time: 4:25 ET
• Location: SoFi Stadium, Inglewood
• TV: FOX

49ers vs Rams

After falling behind early with a 3-0 Vikings lead in their most recent game, the 49ers bounced back with a touchdown from Brock Purdy to Jauan Jennings, taking a 7-3 lead. The Vikings responded with a touchdown, but the 49ers closed out the 2nd quarter with another touchdown from Purdy to George Kittle, giving them a 17-13 lead going into the 2nd half. However, the 49ers were outscored 24-0 in the 2nd half, eventually losing 37-17. This game was tied 37-37 heading into the 4th quarter.

Even though the 49ers were on the road, they were still the favorite, giving -4 points, and the game finished with a combined score of 40 points, falling short of the over/under line of 46.5 points.

After falling behind 14-0 in the first quarter, the Rams lost 41-10 to the Cardinals, dropping their record to 0-2. Los Angeles didn’t have a chance right from the start, as Kyler Murray connected with Marvin Harrison Jr. for two first-quarter touchdowns. The Rams’ only touchdown came late in the 3rd quarter when Kyren Williams rushed for a score.

By halftime, the Rams were down 24-3, and James Conner’s touchdown early in the 3rd quarter put the game out of reach. The Rams were hoping for a better outcome after their 29-yard field goal narrowed the gap to 21-3 in the 2nd quarter, but the Cardinals responded with a field goal of their own. The Rams were also well short of covering the spread with the 31-point loss.

49ers Injury Report

• Christian McCaffrey – Calf/achilles (Out)
• Jon Feliciano – Knee (Out)
• Deebo Samuel Sr. – Calf (Out)
• Dre Greenlaw – Achilles (Out)
• Kalia Davis – Knee (Out)
• Dee Winters – Ankle (Questionable)
• Drake Jackson – Knee (Out)
• Ambry Thomas – Forearm (Out)
• Talanoa Hufanga – Knee (Questionable)
• Elijah Mitchell – Hamstring (Out)
• Ricky Pearsall – Back (Out)

Rams Injury Report

• KT Leveston – Ankle (Out)
• Derion Kendrick – Knee (Out)
• Tre Tomlinson – Undisclosed (Out)
• Puka Nacua – Knee (Out)
• Davis Allen – Back (Questionable)
• Steve Avila – Knee (Out)
• Joe Noteboom – Ankle (Out)
• John Johnson III – Shoulder (Out)
• Conor McDermott – Undisclosed (Out)
• Tyler Higbee – Knee (Out)
• Cooper Kupp – Ankle (Out)
• Larrell Murchison – Arm (Out)
• Jonah Jackson – Shoulder (Out)
• Darious Williams – Hamstring (Out)

49ers Offense Breakdown

In their 23-17 loss to the Vikings, the 49ers’ offense picked up 24 first downs and 297 yards through the air. However, they struggled on third down, converting only 20% of their chances, and their quarterback, Brock Purdy, was sacked six times. Purdy finished the game with 319 yards passing, one touchdown, and an interception, while completing 77.8% of his passes.

Jordan Mason led the team in rushing with 100 yards on 20 carries, including a long run of 22 yards and one touchdown. Deebo Samuel Sr. was the top receiver, with 110 receiving yards.

Rams Offense Breakdown

The Rams’ offense struggled to pick up first downs in their 41-10 loss to the Cardinals, finishing with just 14 first downs. They managed only 192 yards passing and were held without a touchdown. Matthew Stafford completed 70% of his passes for 216 yards but was sacked five times. The running game was equally ineffective, with only 53 yards on 20 attempts.

On the ground, Blake Corum was the leading rusher with 28 yards, while Demarcus Robinson led the team in receiving with 50 yards, 42 of which came on a single catch. Los Angeles converted only 18.2% of their third down attempts.

49ers Team Defense

In their 23-17 loss to the Vikings, the 49ers’ defense struggled to stop the run, giving up 146 yards on just 24 attempts, including a 6.1 yards per attempt average. Despite this, they did manage to come up with four sacks. The 49ers also allowed Minnesota to gain 9.9 yards per pass attempt, resulting in 257 passing yards and two passing touchdowns. San Francisco’s defense forced one interception and allowed the Vikings to convert on 58.3% of their third down attempts.

Rams Team Defense

The Rams’ defense struggled in their most recent game, giving up 41 points in a blowout loss to the Cardinals. Arizona ran for 231 yards on 40 attempts, taking advantage of a run defense that allowed 5.8 yards per attempt. Los Angeles also struggled against the pass, as Arizona completed 81% of their passes for 258 yards, averaging 12.3 yards per attempt and throwing three touchdowns.

On third downs, the Rams allowed the Cardinals to convert 63.6% of their chances. Los Angeles managed just one sack and had a -6 differential in tackles for loss.

49ers vs Rams Trends

• San Francisco has played well in their previous 5 road games, going 3-2 straight up. In this stretch, they averaged 30 points per game while allowing 21. The team also performed well vs the spread at 3-2.
• Through their last five home contests, the Rams offense has averaged 20 points per game while allowing an average of 27. Los Angeles posted an overall record of 2-3 while going 2-3 ATS.
• Through their last three games as the betting underdog, the Rams have a strong record vs the spread going 2-1. Their straight up mark in these contests is 1-2.
• Going back to their last three games as the favorite, the 49ers have a straight up record of 1-2. But, their mark vs the spread was just 1-2.

49ers vs Rams Prediction

Our projected score for this week three matchup between the 49ers and Rams is 24-16 in favor of the Rams. With the point spread sitting at -7 in favor of the 49ers, we are going against the grain and taking the Rams to not only cover but win straight-up.

For this one, we really like the Rams to cover as home underdogs. As for an over/under pick, with the line at 43.5 points, we have these teams finishing with 40 combined points, making the under a solid pick.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.