The Jacksonville Jaguars will face off against the Buffalo Bills at 7:30 ET on Monday, September 23rd. This matchup is being played at Highmark Stadium in Orchard Park.

The Jaguars and Bills will face off on Monday, September 23rd at 7:30 ET, with ESPN covering the week three AFC matchup. The game, being played at Highmark Stadium in Orchard Park, NY, has the Bills favored at -257 on the money line and -5.5 on the point spread. The over/under line is set at 45.5 points.

• Date: Monday, September 23rd
• Time: 7:30 ET
• Location: Highmark Stadium, Orchard Park
• TV: ESPN

Jaguars vs Bills

The Jaguars are now 0-2 after losing to the Browns 18-13. Jacksonville fell behind early, with Deshaun Watson scoring on a 1-yard touchdown run to give Cleveland a 7-0 lead in the 1st quarter. The Jaguars added a field goal in the 2nd quarter but still trailed 13-3 at halftime. Despite being down 16-6 in the 3rd quarter, Trevor Lawrence found Brian Thomas Jr. for a touchdown to make it 16-13. However, the Jaguars were only able to add a field goal in the 4th quarter, and the Browns sealed the game with a late touchdown.

Heading into the game, the Jaguars were favored by -3 points, and the combined 31 points was below the over/under line of 41.5 points. Jacksonville didn’t cover the spread with their 5-point loss. The Browns added a touchdown with 1:48 remaining in the 4th to secure the win.

The Bills are now 2-0 after a 31-10 win over the Dolphins, and Buffalo is undefeated heading into week three. Buffalo’s win over the Dolphins included them taking a 24-10 lead at halftime and then adding a touchdown in the 3rd quarter. Buffalo was on the road for this one and was actually a +2.5 point underdog. The Bills easily covered the spread with their 21-point win, and the 41 combined points was below the over/under line of 49 points.

Buffalo and Miami were tied at 7 after the 1st quarter, but the Bills took control in the 2nd quarter, scoring 17 points. The Bills’ defense forced a key turnover in the 3rd quarter to prevent any chance of a Dolphins comeback. Tua Tagovailoa did find Jaylen Waddle for a touchdown in the 3rd quarter, but by then, Buffalo was already in control of this one.

Jaguars Injury Report

• Darnell Savage – Quad (Questionable)
• Andrew Wingard – Knee (Out)
• Evan Engram – Hamstring (Questionable)
• Tashaun Gipson Sr. – Suspension (Out)
• Tyson Campbell – Hamstring (Out)
• Tank Bigsby – Shoulder (Questionable)
• De’Shaan Dixon – Knee (Out)
• Tyler Lacy – Toe (Questionable)
• David White Jr. – Knee (Out)
• Keilan Robinson – Toe (Out)

Bills Injury Report

• Travis Clayton – Shoulder (Out)
• Javon Solomon – Oblique (Questionable)
• Terrel Bernard – Pectoral (Doubtful)
• Tommy Doyle – Undisclosed (Out)
• Taron Johnson – Forearm (Questionable)
• Shane Buechele – Neck (Out)
• Darrynton Evans – Hamstring (Out)
• Matt Milano – Bicep (Out)
• Dawuane Smoot – Toe (Questionable)

Jaguars Offense Breakdown

The Jaguars’ offense struggled in their 18-13 loss to the Browns, managing just 13 points. They finished with 18 first downs and 297 yards but were inefficient, as they failed to score a touchdown. Trevor Lawrence completed just 46% of his passes for 220 yards and was sacked four times. He didn’t throw any touchdowns but also didn’t have any interceptions.

Jacksonville’s running game showed some promise, averaging 6 yards per attempt on 21 carries for a total of 127 yards. Travis Etienne Jr. led the team with 52 rushing yards, including a long run of 20 yards, and also scored one rushing touchdown. Brian Thomas Jr. was the top receiver with 94 yards, 66 of which came on a single catch.

Bills Offense Breakdown

Josh Allen completed 13 of 19 passes for 139 yards and one touchdown in Buffalo’s 31-10 win over the Dolphins. The Bills’ offense finished with 13 first downs and 139 yards passing. Allen was not sacked in the game and had a passer rating of 107.

James Cook led the rushing attack with 78 yards on 11 carries, including two touchdowns and a 49-yard run. Khalil Shakir was the top receiver with 54 yards on five catches. Buffalo’s offense gained 108 yards on the ground and converted 33.3% of their third down attempts.

Jaguars Team Defense

In their 18-13 loss to the Browns, the Jaguars’ defense gave up 297 yards and held Cleveland to 64.7% completions. They limited the Browns to just 18% on third down and didn’t allow a passing touchdown. The Jaguars’ run defense allowed 125 yards on 29 attempts, with Cleveland averaging 4.3 yards per attempt. Jacksonville did record two sacks and had one more QB hit than the Browns.

Bills Team Defense

In their 31-10 win over the Dolphins, the Bills’ defense picked off three passes and held Miami to just 3-of-8 on third down. Despite giving up 139 yards on the ground, Buffalo allowed just 3.7 yards per attempt. The Bills’ defense also limited the Dolphins to 64.1% completions and allowed just 212 yards passing, with one touchdown.

Buffalo’s defense recorded two sacks and had five more quarterback hits than Miami. The Dolphins finished with 351 total yards, but the Bills were able to force turnovers and keep them out of the endzone for most of the game.

Jaguars vs Bills Trends

• In their last three games away from home, the Jaguars have a straight up record of 0-3 while going 1-2 vs. the spread. The team averaged 16 points per game in this stretch.
• Buffalo has played well in their previous three home games, going 3-0 straight up. In this stretch, they averaged 25 points per game while allowing 15. The team also performed well vs the spread at 2-1.
• Looking back on the team’s last three games as the underdog, the Jaguars have a straight up record of 0-3. Their record vs the spread in these games was 1-2.
• Although the Bills have a strong straight up record in their last five games as the betting favorite, they have not done as well vs the spread going 2-3.

Jaguars vs Bills Prediction

Our pick vs. the spread is to take the Jaguars to cover as road underdogs in this week three matchup between the Jaguars and Bills. The point spread line for this one is sitting at +5.5 in favor of the Jaguars.

As for the over/under, we like the over, with a projected combined score of 48 points and the line currently sitting at 45.5 points.

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All odds are courtesy of Action247 Sportsbook. Good luck!!

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* All odds are provided by Action247 Sportsbook and all odds subject to change.**All views expressed are my own. My picks are my own and are not a guarantee, bet at your own risk.Action247 does not warrant the accuracy of completeness of the information, text, graphics, links or other items contained within these post.